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Recombinant Human Amyloid beta A4 protein (APP) Protein

  • Cat.No.: AP50220HU

  • Reactivity: Human

To Purchase AP50220HU

Size:
100μg 500μg
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Product Details

生产种属 Human
来源 Prokaryotic expression
宿主 E. coli
同义词 ABPP; APPI; APP; A4; AD1
浓度 1 mg/mL
形态 Lyophilized or Liquid
纯度 > 90% as determined by SDS-PAGE
序列 Trp97-Leu128 (P05067)
标签 N-GST.tag and C-His.tag
纯化方式 Affinity purification
分子量 32 kDa
应用 Western blotting,ELISA;SDS-PAGE;Antigen;

产品概述

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction.
 

使用方法

Reconstitute in PBS or others.
 

稳定性

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 

存储

Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.
 

存储缓冲液

Lyophilized from 50mM Tris-cl, 300mM NaCl,pH 9.0
 

注意事项

This product is for research use only, not for diagnostic or therapeutic use.