Rabbit Anti-Mouse LATS1/2 Polyclonal Antibody

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

The antibody is a rabbit polyclonal antibody raised against LATS1/2. It has been selected for its ability to recognize LATS1/2 in ELISA Kit and western blotting.

WB=1:500-2000  ELISA=1:5000-20000  IHC=1:100-300  IF=1:100-300 

Not yet tested in other applications. 

Optimal working dilutions must be determined by the end user.

Shipped at 2-8°C, Store it under sterile conditions at -20°C to -80°C upon receiving.