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  1. Phenolic-enriched Rosa rugosa extract ameliorates obesity-associated metabolic disorders and regulates gut microbiota in high-fat diet-fed mice IF: 3.800
    Obesity is a deleterious medical condition that can lead to lipid metabolism dysregulation and various metabolic disorders. The lipid-reducing and hypoglycemic effects of Rosa rugosa have been demonstrated both in vitro and in vivo. However, the mechanisms of the anti-obesity components and gut microbiota regulating potential of R.
  2. AGO2 protein: A Key Enzyme in the miRNA Pathway as a Diagnostic and 3 Prognostic Biomarker in Adrenocortical Carcinoma IF: 4.100
    Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy characterised by diagnostic challenges, high recurrence rates, and poor prognosis. This study explored the role microRNA (miRNA) processing genes in ACC, and their potential role as diagnostic and prognostic biomarkers.
  3. Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury IF: 8.200
    Traumatic brain injury (TBI) is an acquired insult to the brain caused by an external mechanical force, potentially resulting in temporary or permanent impairment. Microglia, the resident immune cells of the central nervous system, are activated in response to TBI, participating in tissue repair process.
  4. LIPS and PaO2/FiO2 Combined Plasma Biomarkers Predict Onset of Acute Respiratory Distress Syndrome in Patients of High Risks in SICU: A Prospective Exploratory Study IF: 4.664
    Objective. To explore and validate the value of clinical parameters combined with plasma biomarkers for predicting acute respiratory distress syndrome (ARDS) in patients of high risks in the surgical intensive care unit (SICU).
  5. Transcriptional regulation of DLGAP5 by AR suppresses p53 signaling and inhibits CD8+ T cell infiltration in triple-negative breast cancer IF: 4.500
    Triple-negative breast cancer (TNBC) is a challenging subtype with unclear biological mechanisms. Recently, the transcription factor androgen receptor (AR) and its regulation of the DLGAP5 gene have gained attention in TNBC pathogenesis.
  6. The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis IF: 20.500
    Fusobacterium nucleatum can bind to host cells and potentiate intestinal tumorigenesis. Here we used a genome-wide screen to identify an adhesin, RadD, which facilitates the attachment of F.
  7. Tecnologías reproductivas aplicadas a la conservación del visón europeo (Mustela lutreola)
    El visón europeo (Mustela lutreola) es el mamífero más amenazado de Europa, encontrándose en peligro crítico de extinción. En España se estima una población de 142 ejemplares.
  8. Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer´s disease IF: 8.000
    Amyloid plaques, a major pathological hallmark of Alzheimers disease (AD), are caused by an imbalance between the amyloidogenic and non-amyloidogenic pathways of amyloid precursor protein (APP).
  9. Lithium Chloride rescues Monensin-potentiated Wnt signaling inhibition in infl ammatory bone loss in rats
    The aim of the study was to evaluate the effect of Lithium Chloride (LiCl) on animals submitted to Monensin-potentiated periodontal bone loss.
  10. ZEB2 knockdown inhibits interleukin-1β-induced cartilage degradation and inflammatory response through the Wnt/β-catenin pathway in human chondrocytes IF: 2.100
    Osteoarthritis (OA) is a degenerative disease of the joints characterized by inflammation and cartilage degeneration.
  11. Vitamin D status, vitamin D receptor, CYP2R1, and CYP24A1 profiles in children IF: 5.000
    Vitamin D plays a major role in the musculoskeletal and immune system. Understanding the comprehensive mechanism of vitamin D receptors and the enzyme of vitamin D induction (CYP2R1) and inhibition (CYP24A1) in its metabolism is interesting. This study aims to understand vitamin D metabolism in Indonesian pediatrics, specifically in Jakarta, which has abundant sun exposure.
  12. Proteomic Analysis of Caco-2 Cells Disrupted by EcN 1917-Derived OMVs Reveals Molecular Information on Bacteria-Mediated Cancer Cell Migration IF: 4.400
    Escherichia coli Nissle 1917 (EcN 1917) exhibits distinct tumor-targeting activity, and early studies demonstrated that outer membrane vesicles (OMVs) mediate bacteria–host interactions.
  13. Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific Manner IF: 12.800
    Nonalcoholic steatohepatitis (NASH) may soon become the leading cause of end-stage liver disease worldwide with limited treatment options. Liver fibrosis, which is driven by chronic inflammation and hepatic stellate cell (HSC) activation, critically determines morbidity and mortality in patients with NASH.
  14. Anti-osteoporotic effects of enzymatic hydrolysates of mackerel Scomber japonicus byproduct in MC3T3-E1 cells and ovariectomized rat model IF: 1.900
    Recently, interest in fish byproduct-derived bioactive components as potential ingredients for treating and preventing osteoporosis is increasing. In this study, we investigated the antiosteoporotic effects of mackerel Scomber japonicus extracts in MC3T3-E1 preosteoblasts in vitro and ovariectomized rats in vivo.
  15. Adenovirus-specific T cells in adults are frequent, cross-reactive to common childhood adenovirus infections and boosted by adenovirus-vectored vaccines
    Human adenoviruses (HAdVs) cause diverse disease presentations as pathogens, and are also used as viral vectors for vaccines and gene therapy products. Preexisting adaptive immune responses to HAdV are known to influence symptom severity, viral clearance and the success of viral vectored products.
  16. Effects of Erythropoietin-Promoted Fracture Healing on Bone Turnover Markers in Cats IF: 4.800
    In orthopaedics, erythropoietin (EPO) is applied in the preoperative management of anaemic patients, but also as a stimulating factor to assist bone regeneration due to its angiogenic and osteoinductive potential.
  17. AGO2 protein: A Key Enzyme in the miRNA Pathway as a Diagnostic and 3 Prognostic Biomarker in Adrenocortical Carcinoma
    Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Current treatment algorithms are associated with diagnostic limitations, high recurrence rates and poor prognosis. Identifying specific biomarkers that facilitate accurate diagnosis and provide prognostic insights could significantly enhance the patient outcomes in ACC.
  18. Transcriptomics and Metabolomics Unveil the Neuroprotection Mechanism of AnGong NiuHuang (AGNH) Pill Against Ischaemic Stroke Injury IF: 5.100
    As a famous prescription in China, AnGong NiuHuang (AGNH) pill exerts good neuroprotection for ischaemic stroke (IS), but its mechanism is still unclear. In this study, the neuroprotection of AGNH was evaluated in the rat IS model which were established with the surgery of middle cerebral artery occlusion (MCAO), and the potential mechanism was elucidated by transcriptomic analysis and metabolomic analysis.
  19. A 11β-Hydroxysteroid dehydrogenase type 1 (11β- HSD1) inhibitor, 11b-0048, effectively suppresses the expression of 11β-HSD1 activated in cultured keratinocytes and in diabetic murine skin
    Elevated level of active glucocorticoid (GC) deteriorates skin barrier function. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an NADPH-dependent enzyme converting inactive GC to active GC. Elevated active GC due to increased 11β-HSD1 expression might contribute to barrier impairment in aged skin and diabetic skin.
  20. BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development IF: 11.800
    Microglia are highly heterogeneous as resident immune cells in the central nervous system. Although the proinflammatory phenotype of microglia is driven by the metabolic transformation in the disease state, the mechanism of metabolic reprogramming in microglia and whether it affects surrounding astrocyte progenitors have not been well elucidated.
  21. RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1 G93A ALS mice
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by rapid progression and high mortality.
  22. Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration IF: 17.100
    Heart failure is a serious condition that results from the extensive loss of specialized cardiac muscle cells called cardiomyocytes (CMs), typically caused by myocardial infarction (MI).
  23. B-288 The Beginning of the End: AGO2 Protein Identified and Validated as a Novel Biomarker for Multi-cancer Diagnosis Through Bioinformatics Analysis and Immunoassay IF: 9.300
    Despite significant progress in cancer research, the complexity and heterogeneity of the disease still pose major challenges to accurate diagnosis and effective treatment.
  24. Muntingia calabura Leaves Extracts to Ameliorate chronic obstruction pulmonary diseases by Inhibiting IL-17a Signaling: In silico and in vivo studies
    Chronic obstructive pulmonary disease, or COPD, is a disease that commonly breaks the lower respiratory system triggered by continuous exposure to toxic inhalants resulting in oxidative stress accumulation and cascade inflammation process.
  25. Identification of immunological characteristics and cuproptosis-related molecular clusters in Rheumatoid arthritis IF: 5.600
    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by progressive articular damage, functional loss, and comorbidities. The relationship between cuproptosis, a form of programmed cell death, and RA remains unknown.
  26. Tubulin Alpha-1b as a Potential Biomarker for Lung Adenocarcinoma Diagnosis and Prognosis IF: 2.800
    Because lung cancer is the main cause of cancer deaths and lung adenocarcinoma (LUAD) accounts for more than 40% of all lung malignancies, it is essential to develop clinically useful biomarkers for the disease.
  27. Zinc Oxide Nanoparticles Trigger Autophagy in the Human Multiple Myeloma Cell Line RPMI8226: an In Vitro Study IF: 3.900
    Multiple myeloma (MM) is a malignant clonal proliferative plasma cell tumor. Zinc oxide nanoparticles (ZnO NPs) are used for antibacterial and antitumor applications in the biomedical field. This study investigated the autophagy-induced effects of ZnO NPs on the MM cell line RPMI8226 and the underlying mechanism.
  28. Asprosin is positively associated with metabolic syndrome in hemodialysis patients: a cross-sectional study IF: 3.222
    Metabolic syndrome (MS) has a high prevalence in hemodialysis patients. High asprosin levels are associated with the accumulation of adiposity and an increase in body weight, which may drive the development of this syndrome. The relationship between asprosin and MS in patients on hemodialysis has not been investigated.
  29. Mortality, growth, and egg production do not differ between non-transgenic and transgenic female chickens with ubiquitous expression of the 3D8 single chain variable fragment gene IF: 3.352
    To date, many transgenic (TG) chicken lines have been developed, but few studies have performed a comparative analysis of their mortality, growth, and egg productivity.
  30. Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination IF: 8.800
    Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is widely used to simulate demyelination and remyelination occurring in these diseases.
  31. Chronic stress negatively impacts wound healing, welfare, and stress regulation in internally tagged Atlantic salmon (Salmo salar) IF: 4.755
    The desire to understand fish welfare better has led to the development of live monitoring sensor tags embedded within individuals for long periods. Improving and understanding welfare must not come at the cost of impaired welfare due to a tag’s presence and implantation process.
  32. Avaliacao do efeito do cloreto de lítio e monensina na perda óssea inflamatória de ratos submetidos a periodontite experimental
    Periodontite é uma doença crônica marcada pela liberação de mediadores inflamatórios que alteram o metabolismo e arquitetura óssea levando à destruição de estruturas de suporte periodontal. Diversas vias estão envolvidas no processo de perda óssea inflamatória, com destaque mais recentemente para a via WNT canônica, que, quando ativada, estimula diferenciação de osteoblastos. Em condições inflamatórias, o aumento de Dickkopf 1 (DKK-1), induz bloqueio do sítio de ligação de WNT, reduzindo a osteoblastogênese.
  33. Longitudinal Plasma Proteomics-Derived Biomarkers Predict Response to MET Inhibitors for MET-Dysregulated NSCLC IF: 6.575
    MET inhibitors have shown promising efficacy for MET-dysregulated non-small cell lung cancer (NSCLC). However, quite a few patients cannot benefit from it due to the lack of powerful biomarkers.
  34. Uncovering the physiological impacts of soybean meal replacement by Narbonne vetch (Vicia narbonensis) meal in rainbow trout (Oncorhynchus mykiss) diets: Towards the future and sustainable European aquaculture. IF: 3.313
    The identification and implementation of raw materials to replace fish meal (FM) or its major alternative, soybean meal (SBM), among other factors, is crucial for the sustainable growth of aquaculture. Narbonne vetch (Vicia narbonensis) meal (NVM) has previously been identified as a promising alternative raw material locally produced in Europe to replace SBM.
  35. Combined proteomics and single cell RNA-sequencing analysis to identify biomarkers of disease diagnosis and disease exacerbation for systemic lupus erythematosus IF: 8.786
    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease for which there is no cure. Effective diagnosis and precise assessment of disease exacerbation remains a major challenge.
  36. Chicken embryos are a valuable model for the selection of Bacillus subtilis for probiotic purposes IF: 2.667
    Cancer is one of the main causes of death worldwide. Although immunotherapy brings hope for cancer treatment, it is also accompanied by immune checkpoint inhibitor-related adverse events (irAEs).
  37. Comparison of the Effects of Acute Appendicitis and Chronic Cholecystitis on Intestinal Mucosal Function During Surgery
    The objective of this study is to explore the effect of acute appendicitis and chronic cholecystitis on inflammatory factors and intestinal mucosal function during operation.
  38. Selection of Bacillus subtilis for animal and chicken embryo supplementation
    This study aimed to select nonpathogenic strains of B.S., which have beneficial effects on birds and can inhibit Salmonella spp., avian pathogenic Escherichia coli coli (APEC) and Campylobacter jejuni (C.J.).
  39. Antiviral activity of mink interferon alpha expressed in the yeast Pichia pastoris IF: 3.471
    Many viruses can cause infections in mink, including canine distemper virus, mink enteritis virus, and Aleutian disease virus. Current treatments are ineffective, and these infections are often fatal, causing severe economic losses.
  40. Establishment and validation of nomogram for predicting immuno checkpoint inhibitor related pneumonia IF: 3.320
    Cancer is one of the main causes of death worldwide. Although immunotherapy brings hope for cancer treatment, it is also accompanied by immune checkpoint inhibitor-related adverse events (irAEs).
  41. Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing IF: 6.420
    The deposition of β-amyloid (Aβ) in the brain plays a major role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated via amyloid precursor protein (APP) cleavage through the amyloidogenic pathway.
  42. The protective effects of HIF-1α activation on sepsis induced intestinal mucosal barrier injury in rats model of sepsis IF: 3.240
    The integrity of the intestinal barrier is critical for protecting the host against the pathogen. The role of hypoxia-inducible factor-1α (HIF-1α) in the intestinal barrier disfunction related to sepsis remained unclear.
  43. Higher Serum RCAN2 Levels Are Associated with Metabolically Unhealthy Individuals, Either with Obesity or Not
    Regulator of calcineurin 2 (RCAN2) has been documented to cause weight gain and related pathology and metabolism abnormalities in animal researches. The aim of the study was to compare serum RCAN2 concentrations in metabolically healthy (MH) and metabolically unhealthy (MUH) individuals.
  44. Xuedan Sustained Release Pellets Ameliorate Dextran Sulfate Sodium–Induced Ulcerative Colitis in Rats by Targeting Gut Microbiota and MAPK Signaling Pathways IF: 5.810
    Cucurbitacins have a variety of bioactivities, such as anticancer, anti-inflammatory, antidepressant-like, and antiviral effects, but their pharmacological effect in ulcerative colitis (UC) has not been reported until now.
  45. Effect of dexmedetomidine up-regulating HIF-1ɑ on intestinal mucosal barrier injury related to sepsis in rats
    Dexmedetomidine (DEX), a highly selective α2 receptor agonist. DEX can inhibit the release of inflammatory factors in septic rats.
  46. Elevated Serum Regulator of Calcineurin 2 is Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease IF: 5.810
    The promoting effect of the regulator of calcineurin 2 (RCAN2) in hepatic steatosis has been observed in animal studies. However, the association of RCAN2 with non-alcoholic fatty liver disease (NAFLD) in humans remains unclear.
  47. Association between IL-10 systemic low level and highest pain score in patients during symptomatic SARS-CoV-2 infection IF: 3.183
    Despite the wide variety of Covid-19 symptoms, pain and the related mechanisms underlying unsettled nociceptive status are still under-prioritized. Understanding the complex network of Covid-19-related pain may result in new lines of study.
  48. Myosin light chain 9 promotes the proliferation, invasion, migration and angiogenesis of colorectal cancer cells by binding to Yes-associated protein 1 and regulating Hippo signaling IF: 3.269
    Colorectal cancer is a common type of cancer with high incidence and poor prognosis. Increased expression of myosin light chain 9 (MYL9) has been reported in early-stage and recurrent colorectal cancer tissues.
  49. Microengineered Multi-Organoid System from hiPSCs to Recapitulate Human Liver-Islet Axis in Normal and Type 2 Diabetes IF: 16.806
    Type 2 diabetes mellitus (T2DM) is a systematic multi-organ metabolic disease, which is characterized by the dynamic interplay among different organs.The increasing incidence of T2DM reflects an urgent need for the development of in vitro human-relevant models for disease study and drug therapy.
  50. Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds IF: 3.935
    Anemarrhenae rhizome and Phellodendri cortex have historically been used for the treatment of precocious puberty (PP) in oriental medicine.Our study aimed to evaluate the effect of APE, a mixture of the extracts from these herbs, against danazol-induced PP in female rats.
  51. Athrixia phylicoides tea infusion (bushman tea) improves adipokine balance, glucose homeostasis and lipid parameters in a diet-induced metabolic syndrome rat model IF: 3.470
    Central obesity and insulin resistance are associated with metabolic syndrome (MetS) which is aggravated by diet and sedentary lifestyle. Athrixia phylicoides (AP) is reported by rural communities to have medicinal benefits associated with MetS such as obesity and type 2 diabetes.
  52. Effects of HIF-1α agonist or inhibitor on intestinal mucosal permeability in rats with sepsis IF: 0.552
    Objective To investigate the effects of sepsis and HIF-1α agonist or inhibitor on intestinal mucosal barrier function.Methods SD rats were randomly divided into sham operation group (sham), Sepsis group treating with cecal ligation and perforation (CLP), Sepsis+HIF-1α agonist group (sepsis + DMOG) receiving intraperitoneal injection of HIF-1α agonist DMOG (40 mg/kg) for 7 consecutive days before CLP, Sepsis+HIF-1α inhibitor group (sepsis+BAY87-2243) orally administered with HIF-1α inhibitor BAY87-2243 (9 mg/kg) for 3 consecutive days before CLP.
  53. Serum Mitochondrial Quality Control Related Biomarker Levels are Associated with Organ Dysfunction in Septic Patients IF: 3.454
    To investigate the feasibility and the value of using mitochondrial quality control (MQC)-related proteins as biomarkers in septic patients.The enrolled subjects were divided into four groups: healthy control group (n = 30), intensive care unit (ICU) control group (n = 62), septic nonshock group (n = 40), and septic shock group (n = 94). Serum levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), fission protein 1 (Fis1), mitofusin2 (Mfn2), and Parkin were measured by enzyme-linked immunosorbent assay at the time of enrollment for all groups. Clinical parameters and laboratory test results were also collected.
  54. Effect of yeast culture on growth performance, apparent nutrient digestibility and rumen fermentation parameters of beef cattle IF: 1.39
    The experiment studied the effect of adding yeast culture to feed on growth performance, nutrient digestibility, fermentation parameters and antioxidant function of Simmental hybrid cattle.
  55. Application of nano-silver antibacterial hydrogel dressing combined with recombinant human basic fibroblast growth factor on wound healing after debridement of open ankle fracture IF: 1.650
    Nano-silver antibacterial dressings and hydrogels are both new types of dressings used for the treatment of infected wounds. Recombinant human basic fibroblast growth factor is an active peptide drug commonly used for open wounds.
  56. Comprehensive Analysis of DOK Family Genes Expression, Immune Characteristics, and Drug Sensitivity in Human Tumors IF: 6.992
    DOK is a new type of regulatory protein family that participates in the regulation of tumor cell growth. However, most of the studies are conducted in cell lines, and systematic studies have not been conducted in human tumors.
  57. L-Carnitine Ameliorates the Muscle Wasting of Cancer Cachexia through the AKT/FOXO3a/MaFbx Axis IF: 3.211
    Recent studies suggest potential benefits of applying L-carnitine in the treatment of cancer cachexia, but the precise mechanisms remain unknown. This study was conducted to determine the mechanism by which L-carnitine reduces cancer cachexia.
  58. Prognostic Significance of the Fission1/Parkin Ratio for Sepsis: A Prospective Cohort Study IF: 3.900
    Fission1 (Fis1) and parkin are key proteins related to mitochondrial fission and mitophagy, respectively. This study aimed to assess the prognostic value of the Fis1/parkin ratio as a biomarker in patients with sepsis.
  59. TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages IF: 3.919
    TP53-induced glycolysis and apoptosis regulator (TIGAR) is now characterized as a fructose-2,6-bisphosphatase to reduce glycolysis and protect against oxidative stress. Recent studies have demonstrated that TIGAR is associated with cardiovascular disease.
  60. Effects of photoperiod and light intensity on milk production and milk composition of dairy cows in automatic milking system IF: 1.685
    The purpose of this study was to determine the effects of photoperiod and light intensity on milk production, milk composition, hormones levels and blood metabolites indices of Korean Holstein dairy cows in automatic milking system (AMS).
  61. The Correlation between serum Asprosin levels and bone mineral density, balance ability and fracture incidence in postmenopausal women IF: 1.439
    Objective To explore the correlation between serum asprosin levels and bone mineral density (BMD), balance ability and fracture incidence in postmenopausal women. Methods The clinical data of 164 postmenopausal women with osteoporosis (OP) admitted to our hospital were retrospectively analyzed.
  62. Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy IF: 4.074
    Small extracellular vesicles (sEVs) derived from the plasma have been increasingly recognized as important vehicles of intercellular communication and potential sources of new biomarkers for multiple diseases. In this study, proteomic profiles of plasma sEVs from normal subjects and diabetic patients with or without diabetic retinopathy (DR) were systematically compared using iTRAQ-based quantitative proteomics.
  63. Circulating Exosomal Integrin β3 Is Associated with Intracranial Failure and Survival in Lung Cancer Patients Receiving Cranial Irradiation for Brain Metastases: A Prospective Observational Study IF: 6.126
    Brain metastasis (BM) is a major problem in patients with cancer. Exosomes or extracellular vesicles (EV) and integrins contribute to the development of BM, and exosomal integrins have been shown to determine organotropic metastasis.
  64. Preventive Effectof Traditional Chinese Medicine Extractive on SPF Chicks Inoculated with IBDV IF: 0.857
    In order to investigate the preventive effect of traditional Chinese medicine extractive (TCME) on SPF chicks inoculated with IBDV.
  65. Effects of Estrogen Inhibition Formula Herbal Mixture for Danazol-induced Precocious Puberty in Female Rats: An Experimental Study with Network Pharmacology IF: 2.172
    This study aimed at determining the effect of the herbal mixture estrogen inhibition formula (EIF) and its possible mechanisms by precocious puberty animal models and network pharmacology-based analysis.
  66. Magnesium-pretreated periosteum for promoting bone-tendon healing after anterior cruciate ligament reconstruction IF: 10.317
    Periosteum can improve tendon-bone healing when applied to wrap the tendon graft in both animal studies and clinical trials. As magnesium (Mg) ions can significantly elevate the levels of relevant cytokines involving in the osteogenic differentiation of periosteum-derived stem cells, the Mg-pretreated periosteum may be an innovative approach for enveloping the tendon graft.
  67. Effects of Replacing Corn with Hydroponically Sprouted Barley on the Growth Performance and Blood Metabolite Status of Holstein Dairy Heifers IF: 2.480
    This study aimed to determine the effects of replacing corn with hydroponically sprouted barley (HSB) in Holstein heifer feed on growth performance and blood metabolites. For this purpose, the barley was prepared with hydroponic sprouting under optimized conditions, and its chemical composition was analyzed on a dry matter (DM) basis.
  68. 3D Fabrication of PCL Micro-Scaffolds with Interconnected Flow-Channel and Perfusion Culture for In Vitro Construction of Functional Islet Tissue
    A novel micro-scaffold with interconnected flow-channel facilitating mass transfer was designed as a rigid structure to sustain dynamic perfusion culture towards engineering functional islet tissues. Biodegradable polycaprolactone (PCL) micro-scaffolds, having around 69.2% porosity with a pore size of 10 μm, were fabricated via casting technology using polyvinyl alcohol (PVA) mold printed by fused deposition modeling (FDM).
  69. Effects of Nyuhuang Fuzheng Granule on the Humoral Immunity Function and Antioxidant Capacity of Rat IF: 0.776
    The aim of this study was to investigate the effects of Nyuhuang Fuzheng Granule on humoral immune function and antioxidant capacity in rats. Eighty rats were randomly divided into the blank group and the high, medium and low dose groups of Nyuhuang Fuzheng Granule, with 20 rats in each group.
  70. C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins-possible link to metabolic programming? IF: 2.742
    Children born small for gestational age (SGA) are at increased risk of future glucose intolerance and type 2 diabetes, possibly after due intrauterine metabolic programming. Soluble leptin receptor (SLR) limits leptin access to signal-transducing membrane receptors.
  71. High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction IF: 2.028
    OX40 ligand (OX40L) is a member of tumor necrosis factors (TNF)/TNFR super family and is mainly expressed in activated T cells and participates in various inflammatory reactions. However, it remains unclear about the role of serum OX40L as a biomarker of cerebral infarction (CI).
  72. Administration of L. salivarius expressing 3D8 scFv as a feed additive improved the growth performance, immune homeostasis, and gut microbiota of chickens IF: 1.301
    Probiotics have been defined as live microorganisms that are administered in an appropriate amount to provide health benefits to the host animal.
  73. The sIgA and histatin-5 expressions in saliva of early childhood caries and caries-free children based on period times
    To analyze the level of sIgA and Histatin-5 expression in Early Childhood Caries (ECC) and caries-free children. Saliva was collected from 31 subjects of ECC and 29 caries-free (ages 9-32 months). The level expression of sIgA and Histatin 5 was analyzed by enzyme-linked immunosorbent assay.
  74. Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles IF: 6.561
    Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO2 NPs) have been increasingly exposed to the environment and the public. However, the health effects of oral exposure of TiO2 NPs are still controversial.
  75. Effects of oral exposure to titanium dioxide nanoparticles on gut microbiota and gut-associated metabolism in vivo IF: 6.970
    The antibacterial activity of titanium dioxide nanoparticles (TiO2 NPs) has been extensively documented and applied to food packaging or environmental protection. Ingestion of TiO2 NPs via dietary and environmental exposure may pose potential health risks by interacting with gut microbiota.
  76. Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line IF: 0.248
    Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell proliferation of corticotroph adenomas. This study aimed to examine whether OXT affects cell growth in pituitary tumor cell lines (AtT20 and GH3 cells) with a focus on corticotroph adenoma cells.
  77. Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes IF: 2.776
    Asprosin is a counter-regulatory hormone to insulin which plays a role in fasting. It may therefore also play a role in hypoglycaemia unawareness, which has been subsequently examined in this pilot study.Intravenous glucose tolerance test was used to induce controlled hyperglycemia whereas a hyperinsulinemic clamp test was used to induce a controlled hypoglycaemia in 15 patients with diabetes type 1, with and without hypoglycaemia unawareness.
  78. Expression of lysyl oxidase-like 2 in cholangiocarcinoma and its relations with vascular endothelial growth factor A and angiogenesis IF: 1.772
    To investigate the expression of lysyl oxidase-like 2 (LOXL2) in cholangiocarcinoma (CCA) and its association with angiogenesis in CCA.The relevant data were downloaded from the GEO database, and then, the difference in LOXL2 mRNA expression between CCA tissue and tumor adjacent tissue was compared.
  79. Growth, physiological, and molecular responses of golden pompano Trachinotus ovatus (Linnaeus, 1758) reared at different salinities IF: 3.014
    Golden pompano (Trachinotus ovatus) is a commercially important marine fish and is widely cultured in the coastal area of South China. Salinity is one of the most important environmental factors influencing the growth and survival of fish. The aims of this study are to investigate the growth, physiological, and molecular responses of juvenile golden pompano reared at different salinities. Juveniles reared at 15 and 25‰ salinity grew significantly faster than those reared at the other salinities.
  80. The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma IF: 3.571
    Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer after hepatocellular carcinoma. Antiangiogenic therapy has been administered to patients with CCA, but the benefits of this therapy remain unsatisfactory. Improved understanding of the molecular mechanisms underlying angiogenesis in CCA is required.
  81. Oral administration of Lactobacillus reuteri expressing a 3D8 single-chain variable fragment (scFv) enhances chicken growth and conserves immune homeostasis IF: 1.497
    The present study was aimed to investigate the effects of 3D8 scFv-secreting Probiotic Lactobacillus reuteri (L. reuteri) on growth performance, inflammatory responses, and intestinal microbial flora in chickens.
  82. Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF-κB-mediated inflammatory IF: 1.851
    The inflammatory response plays a vital role in cerebral aneurysm (CA) formation and progression. Tanshinone IIA (Tan IIA) is one of the major active components of Chinese medicine Danshen (Salvia miltiorrhiza Bunge) and is widely used for the treatment of cardiovascular diseases, due to its anti-inflammatory effects.
  83. Macc1 promotes angiogenesis in cholangiocarcinoma by upregulating VegFa IF: 3.046
    Angiogenesis actively contributes to tumor growth and metastasis. MACC1 was reported to be associated with tumor progression. In the present study, we aimed to investigate the expression and role of MACC1 in cholangiocarcinoma (CCA) and its correlation with angiogenesis.
  84. Astrocytic damage in glial fibrillary acidic protein astrocytopathy during initial attack IF: 3.199
    Determination of glial fibrillary acidic protein (GFAP), aquaporin 4 (AQP4), and myelin oligodendrocyte glycoprotein (MOG) levels in cerebrospinal fluid (CSF), and astrocytic damage analysis in patients with GFAP astrocytopathy (GFAP-A) and other conditions.
  85. Effect of Short-distance Walking Activity on Milk Production and Metabolic Status of Lactating Dairy Cows IF: 1.129
    In this study, the effect of daily short-distance walking exercise on milk production and metabolic status of the lactating dairy cows was investigated. From this study, we suggest that walking activity can be improved energy balance. Further investigation is needed to determine whether different combinations of distance, rate or doing in morning or afternoon will stimulate energy balance.
  86. NLRC5: potential novel non-invasive biomarker for predicting and refecting the progression of IgA nephritis IF: 4.197
    The nucleotide oligomerization domain-like receptor subfamily C5 (NLRC5) is primarily expressed in the adaptive and innate immune systems. NLRC5 was recently discovered to regulate immunity and infammatory responses. Abnormal immune and infammatory responses are considered critical pathogenesis in IgA nephritis (IgAN).
  87. The effect of shear on the cytoskeleton remodeling and physiological performance of myocardium cells through Tmod1 IF: 2.936
    Mechanical stimulation alters cell metabolism, but little is known about the effects of mechanical strain on the cytoskeleton of myocardium cells. This study was to investigate the changes of Factin, a cytoskeleton protein of myocardium cells, and to provide a theoretical basis for further investigation of the mechanism of myocardium-remodeling.
  88. Roles of TREM2 in degeneration of human nucleus pulposus cells via NF‐κB p65 IF: 2.959
    Nuclear factor (NF)-κB p65 plays a key role in the development of intervertebral disc degeneration (IDD). Herein, we found that messenger RNA levels of human triggering receptor expressed on myeloid cells‐2 (TREM2) and NF‐κB p65 were upregulated and strongly positive correlated (r2 = 0.299, P = 0.0126) in nucleus pulposus (NP) tissues of patients with IDD.
  89. Antagonistic effects of different selenium sources on growth inhibition, oxidative damage, and apoptosis induced by fluorine in broilers IF: 2.216
    Fluorosis can induce oxidative stress through leading to reactive oxygen species (ROS) generation. Selenium (Se) can eliminate ROS by direct and indirect manners. In this study, therefore, we investigated the possible protective effects of sodium selenite (SS) and selenomethionine (Se-Met) on fluorine (F)-induced oxidative stress in broilers.
  90. NLRC3: A Novel Noninvasive Biomarker for Pulmonary Hypertension Diagnosis IF: 5.058
    The nucleotide-oligomerization domain (NOD)-like receptor subfamily C3 (NLRC3) is a newly discovered and incompletely characterized member of the NLR family which negatively regulates inflammatory responses. Inflammation is considered a critical pathogenesis in pulmonary hypertension (PH).
  91. Reproductive and endocrine-disrupting toxicity of Microcystis aeruginosa in female zebrafish IF: 8.943
    Microcystis aeruginosa, a primary species in cyanobacterial blooms, is ubiquitously distributed in water. Microcystins (MCs) purified from M. aeruginosa can exert reproductive toxicity in fish. However, the effects of M. aeruginosa at environmentally relevant levels on the reproductive and endocrine systems of zebrafish are still unknown.

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